Serotonin modulates glutamatergic transmission to neurons in the lateral habenula
نویسندگان
چکیده
The lateral habenula (LHb) is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin receptors. However, actions of serotonin on the excitatory synaptic transmission to LHb neurons have not been thoroughly investigated. The LHb contains two anatomically and functionally distinct regions: lateral (LHbl) and medial (LHbm) divisions. We compared serotonin's effects on glutamatergic transmission across the LHb in rat brains. Serotonin bi-directionally and differentially modulated glutamatergic transmission. Serotonin inhibited glutamatergic transmission in higher percentage of LHbl neurons but potentiated in higher percentage of LHbm neurons. Magnitude of potentiation was greater in LHbm than in LHbl. Type 2 and 3 serotonin receptor antagonists attenuated serotonin's potentiation. The serotonin reuptake blocker, and the type 2 and 3 receptor agonists facilitated glutamatergic transmission in both LHbl and LHbm neurons. Thus, serotonin via activating its type 2, 3 receptors, increased glutamate release at nerve terminals in some LHb neurons. Our data demonstrated that serotonin affects both LHbm and LHbl. Serotonin might play an important role in processing information between the LHb and its downstream-targeted structures during decision-making. It may also contribute to a homeostatic balance underlying the neural circuitry between the LHb and raphe nuclei.
منابع مشابه
Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin
The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the...
متن کاملPM316. Carbachol attenuates excitatory synaptic transmission in cholinergic neurons of the laterodorsal tegmental nucleus
s | 13 increase that induced by the infusion of μ-opioid receptor agonist DAMGO in the NAc were significantly suppressed by acute PF11 administration. Conclusions: The present data indicate that PF11 inhibits METHinduced dependence and dopaminergic hyperfunction by regulating GABAergic and opioidergic neuronal system in the NAc of mice. And it is proposed that PF11 could be a useful compound fo...
متن کاملPM317. Characterization of nicotinic neural activities in rat medial and lateral habenula
s | 13 increase that induced by the infusion of μ-opioid receptor agonist DAMGO in the NAc were significantly suppressed by acute PF11 administration. Conclusions: The present data indicate that PF11 inhibits METHinduced dependence and dopaminergic hyperfunction by regulating GABAergic and opioidergic neuronal system in the NAc of mice. And it is proposed that PF11 could be a useful compound fo...
متن کاملInvolvement of lateral habenula-dorsal raphe neurons in the differential regulation of striatal and nigral serotonergic transmission cats.
The importance of the lateral habenula-dorsal raphe pathway in the control of in vivo [3H]serotonin release in the cat basal ganglia was examined using the push-pull cannula technique and an isotopic method for the estimation of [3H]serotonin continuously formed from [3H]tryptophan. [3H]Serotonin was measured in both caudate nuclei and substantiae nigra and, in some cases, in the dorsal raphe. ...
متن کاملPM318. Spicy food preference and the HPA axis reactivity to stress in Korean social drinkers
s | 13 increase that induced by the infusion of μ-opioid receptor agonist DAMGO in the NAc were significantly suppressed by acute PF11 administration. Conclusions: The present data indicate that PF11 inhibits METHinduced dependence and dopaminergic hyperfunction by regulating GABAergic and opioidergic neuronal system in the NAc of mice. And it is proposed that PF11 could be a useful compound fo...
متن کامل